Found 134 matching trials
Fulvestrant +/- Akt Inhibition in Advanced Aromatase Inhibitor Resistant Breast Cancer
PHASE1This is a two stage study, with an initial dose escalation phase I study an...
Status
Active Not Recruiting
Location
Velindre NHS Trust
Safety, Pharmacokinetics (PK) of AKT and MEK Combination
PHASE1This study is a Phase 1 dose-escalation open-label study to determine the r...
Location
GSK Investigational Site
Akt Inhibitor MK2206 and Hydroxychloroquine in Treating Patients With Advanced Solid Tumors, Melanoma, Prostate or Kidney Cancer
PHASE1This phase I trial studies the side effects and the best dose of Akt inhibi...
Status
Active Not Recruiting
Location
Rutgers Cancer Institute of New Jersey
Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Metastatic Triple-Negative Breast Cancer
PHASE2This phase II trial studies how well trametinib and v-akt murine thymoma vi...
Location
MedStar Georgetown University Hospital
PIK3CA/PTEN-altered Advanced Breast Cancer Treated With MEN1611 Monotherapy or in Combination With Eribulin
PHASE2The multicenter, two-cohort, non-comparative, open-label, phase II clinical...
Status
Active Not Recruiting
Location
Hospital Universitario Clínico San Cecilio de Granada
Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma
PHASE2This phase II clinical trial studies how well Akt inhibitor MK2206 works in...
Location
M D Anderson Cancer Center
RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial Cancer
PHASE2This research study is studying a combination of targeted therapies as a po...
Location
Massachusetts General Hospital Cancer Center
Immunotherapy Plus Capivasertib for Metastatic Bladder Cancer
PHASE1This study aims to determine whether adding an oral medication called Capiv...
Location
VA Connecticut Healthcare System West Haven Campus, West Haven, CT
Study of Oral PQR309 in Patients With Advanced Solid Tumors
PHASE1This is an open-label, multi-center, non-randomized, dose escalation Phase ...
Location
M.D. Anderson Cancer Center
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
PHASE3This study will assess the efficacy and safety of capivasertib plus docetax...
Status
Active Not Recruiting